Integrin alpha-v beta-3
《英文msh詞典》Integrin alpha-v beta-3
[入口詞] Integrin alpha-v beta-3
[主題詞] Integrin alphaVbeta3
[中文釋義] 整合素α-v β-3
[英文釋義] An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells,and in some tumor cells,where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS,VITRONECTIN).